Zou Bin
Shanghai Blueray Bio-pharma Co. Ltd., China
Title: Discovery of EED inhibitor BR554: Preclinical candidate as anti-cancer therapy
Biography
Biography: Zou Bin
Abstract
WD40 repeat (WDR) domain is one of the largest protein families from yeast to human, consisting about 1% total cell protein. WDR proteins generally function as platform of protein-protein interactions and are involved in a wide range of cellular processes. Embryonic Ectoderm Development (EED), a subunit of PRC2 complex, is an important member of WDR family and plays critical role of methylating H3K27. Herein, a novel class of EED inhibitors, represented by BR554, with great drug-like properties, in vivo efficacy and favorable toxicology profile.