Bing Zhang is the Chief of Clinical Chinese Pharmacy in Beijing University of Chinese Medicine and Chief of Center for Chinese Pharmacovigilance and Rational Use of Chinese Medicine. She has researched on the prevention and treatment of metabolic diseases. She had published more than 300 papers as first or correspondence author.
Hyperuricemia is characterized by high levels of serum uric acid which is related with impairments of urate excretion closely. It is commonly accepted that the kidney is an important organ which is responsible for two-thirds of urate excretion. At the same time, the gut is also an essential excretive pathway for hyperuricemia which take charge of the remaining third urate excretion. Thus, the drug which could promote renal-pathway and extra-renal/intestinal-pathway of urate excretion may be valued for urate-lowering treatment. Chicory is a traditional Chinese medicine. Functions of it are diuresis and detumescence and it is also could be applied to treat spleen insufficiency. Our previous studies found chicory was excellent in uric acidlowering. Currently, we observed whether the uricosuric effect of chicory is benefited by renal and/or intestinal pathways. We chose two kinds of animal model in present research, quails and rats. Quail, an ideal animal for hyperuricemia due to its similar metabolism pathway with human, was fed with 15% yeast. Rats were administrated with 10% fructose-drinking. All of model animals in our studies showed the sustained high level of serum urate level during experimental days. Meanwhile, results showed that chicory extract decreased the serum urate levels of these two kinds of animal models significantly, and increased urate levels of in excreta of hyperuricemia quails obviously, as well as promoted the urate excretion in the urine and feces of hyperuricemia rats. As of now, it is thought that chicory may be a promising anti-hyperuricemia agent both from renal pathway and intestinal pathway of urate excretion. Next, we will further explore the possible mechanism of the uricosuric effect of chicory underlying the urate transporter responsible for renal pathway and intestinal pathway separately.
Genki Murakami has his expertise in public health and management engineering especially safety management in hospital. He practices the hospital's safety management method using the resilient engineering, which is safety management method based on ergonomics. He has completed his graduation in Management Engineering and Public Health.
There is an increasing focus on the prevention of Deep Vein Thrombosis (DVT) in medical care from the perspective of healthcare safety. However, when implementing preventive measures, physicians will first conduct an overall evaluation of each patient’s condition and may choose to administer measures that deviate from these guidelines to ensure optimal treatment. The aim of this study was to ascertain and conduct a descriptive analysis of resilience in the implementation of DVT preventive measures in a tertiary care teaching hospital in Japan. The study sample comprised patients who had been newly admitted to the subject hospital between October 2016 and September 2017 and had undergone DVT risk assessments during hospitalization. Data were collected on the results for each risk assessment item and the final assessed risk, as well as on the preventive measures implemented for each patient. Among the patients who had undergone DVT risk assessments at the subject hospital, there were 5,311 patients who had undergone surgery, 549 patients who were prescribed bed rest for 48 hours or more and 7,045 patients who did not require any bed rest. Regardless of surgical status, there were 5,059 patients with moderate DVT risk; among these, 1,008 patients were administered preventive measures that were less stringent (i.e., early ambulation and active mobilization only) than those prescribed in the guidelines. There is a trade-off between preventing DVT and mitigating the risk of hemorrhage and physicians must implement the most appropriate DVT prevention strategy based on each patient’s condition. The adoption of resilience measures that allow deviations from conventional rules can be effective for non-standard cases. However, such deviations must be supported by each physician’s specialized expertise and experience and should not be implemented lightly.