Day 1 :
Keynote Forum
Bernard M Y Cheung
University of Hong Kong, Hong Kong
Keynote: Impact of the latest guidelines on the management of hypertension
Time : 09:30-10:15
Biography:
Bernard M Y Cheung went to Sevenoaks School and graduated from the University of Cambridge. He was a British Heart Foundation Junior Research Fellow at Cambridge before taking up Lectureships in Sheffield and Hong Kong. From 2007-2009, he held the chair in Clinical Pharmacology and Therapeutics in Birmingham. He is the Head of the Division of Clinical Pharmacology and Therapeutics in the Department of Medicine of the University of Hong Kong. He is an Honorary Consultant Physician of Queen Mary Hospital and the Medical Director of the Phase 1 Clinical Trials Centre. He is the Editor-in-Chief of Postgraduate Medical Journal. His main research interest is in cardiovascular diseases and risk factors, including hypertension and the metabolic syndrome.
Abstract:
The latest American guidelines (ACC/AHA) on the prevention, detection, evaluation and management of high blood pressure marked a paradigm shift in the management of hypertension. The new definition of hypertension includes a systolic blood pressure of 130-139 mmHg or a diastolic blood pressure of 80-89 mmHg. What used to be regarded as prehypertension is now included in the definition of hypertension. This makes a sizeable proportion of the general population hypertensive. In USA, 45.6% of the adult population is deemed to be hypertensive. This is fine in a society in which a disease label entitles people to be reimbursed for medical treatment, but for less developed countries, this poses a challenge. Nevertheless, tackling hypertension at an earlier stage is cheaper than treating the complications of hypertension. Americans with stage-1 hypertension are mostly overweight without cardiovascular complications yet. Stage-1 hypertension can therefore be managed initially by changing lifestyle. For those with a certain level of cardiovascular risk (e.g. 10-year atherosclerotic cardiovascular disease risk of 10% or higher), drug treatment should be considered. Fortunately, stage-1 hypertension is relatively easy to control. Our network meta-analysis of clinical trials suggested that the ACC/AHA target of <130/80 mmHg is associated with reduction in the risk of cardiovascular events.
Keynote Forum
Yona Barak
Dr Yona Barak Laboratories LTD, Israel
Keynote: Intra-cytoplasmic morphologically selected sperm injection: A tool for selecting the best sperm in real time for the proper patient
Time : 10:15-11:00
Biography:
Yona Barak has graduated with MSc and PhD degrees. She established many IVF programs worldwide as a part of a team in 1984 the Tel Aviv Medical Center; where she operated the IVF laboratory as the Director for 12 years. In 1986 she was one of the Founders and Owners of the IVF unit at the Herzliya Medical Center and worked as the Director of the laboratory for about 25 years. In 1996 established and became a Lecturer and the Clinical Director of the MSc program of Gametology and Embryology in Bar Ilan University, Israel.
Abstract:
Intra-Cytoplasmic Sperm Injection (ICSI) in humans was first introduced in 1992. ICSI enabled to achieve fertilization, embryo development and pregnancies. It seemed that the importance of routine parameters of sperm morphology decreased in the field of assisted reproduction. However, one of the main concerns in ICSI is the aspiration of good-quality spermatozoa for microinjection into an oocyte. Practically, the injected spermatozoa are randomly chosen and their selection is based on rough morphologic aspects and motility. Sperm morphology is the only criteria for sperm aspiration during ICSI. Routine sperm criteria are based on the raw ejaculate stained sperm cells. Thus, it is important to score and aspirate a good quality motile spermatozoon, which will contribute to the quality of the developing embryo after ICSI, in real time of the procedure. In ICSI, assessment of sperm morphology is limited due to the low magnification (200 X-400 X) and concomitant low resolution. It has been demonstrated that by using intra-cytoplasmic morphologically selected sperm injected, a spermatozoon with normal morphology, and more precisely normal nucleus, might affect the incidence of pregnancy. Although the usage of Intracytoplasmic Morphologically selected Sperm Injection (IMSI) is currently wider, it is necessary to standardize which sperm to aspirate, due to criteria based on accumulating data. Moreover, the benefits of IMSI could be noticeable in cases of patients with repeated implantation failures, severe male factor infertility and advanced paternal and maternal age. The magnified on screen image obtained in IMSI, is a combination of the magnification of the objective, the camera adapter, ratio between the diagonal screen size in mm, diagonal of the camera chip size in mm and internal magnification of the microscope. Final values obtained (up to X 6000 and more) is the amplification of the surface of the sperm cell image, not observed by the routine X 200400 in ICSI, due to objective limitations of the human eyes. IMSI is still considered as a controversy technical and laboratory procedure, however, it seems to become a promising procedure in terms of improving the outcome of ICSI treatments.
Break: Networking & Refreshments Break: 11:00-11:30 @ Foyer
- Workshop
Location: Vivaldi (4th Floor)
Session Introduction
Judith Coulson-Geissmann
Coulson Holding Co. Ltd, Thailand
Title: Self-care for healthcare professionals: Connection between individual well-being and the ability to care for others
Time : 11:30-12:30
Biography:
Judith Coulson-Geissmann is a Certified Corporate Wellness Specialist, nutrition and lifestyle expert. She has focused her ongoing education and research on the effects of nutrition and lifestyle choices on community culture and behavior and the subsequent effects on population wellbeing and health. Currently she is pursuing her MSc in Applied Positive Psychology and Coaching Psychology to better understand the emotional and mental aspect of health and well-being.
Abstract:
Impaired physician and healthcare professionals can have a direct impact on patient health care and safety. While some problems of alcoholism and substance abuse among physicians have been addressed, basic concepts like healthy food and lifestyle choices, as well as mental health issues are still widely ignored. While patient safety is paramount, the medical profession might be more successful in achieving the required standards by fostering a culture committed to self-care, health and wellness. Burnout is a common syndrome seen in healthcare workers, particularly physicians and emergency staff, who are exposed to a high level of stress at work. A survey of the topic, taken in 2011, found that close to half of doctors, 45% experienced at least one component of burnout, meaning they are emotionally exhausted, often treat patients as objects, or have lost their sense of purpose. Three years later, the survey numbers got worse. In 2014, burned-out doctors made up 54% of the profession. The time has come for academic medicine to lead by example for the population and to practice what they preach. To do this, we must first develop a shared understanding of physician wellness followed by interventional strategies that lead to a cultural change, including a more positive educational environment for residents and faculty. We need to raise the awareness of self-care and its relation to health, well-being and burnouts. There is a need to create an environment that allows the admitting of burnout symptoms, enable the development of preventive strategies and create a more positive, strength-based approach to health care professional’s own health and well-being.
- Sessions
Session Introduction
Zou Bin
Shanghai Blueray Bio-pharma Co. Ltd., China
Title: Discovery of EED inhibitor BR554: Preclinical candidate as anti-cancer therapy
Time : 12:30-13:00
Biography:
Zou Bin is the Co-Founder and CEO of Shanghai Blueray Biopharma, Co., Ltd since 2017. He had more than ten years’ experience in global pharma at Novartis Institute for Tropical Diseases, Singapore and discovered antimalarial drug NITD609 to phase II clinical trial. He did a Postdoctoral research with Prof. K. C. Nicolaou in the lab cofounded with A*STAR. He has obtained his PhD from Shanghai Institute of Organic Chemistry under the supervision of Prof. Dawei Ma, after his undergraduate from Nankai University. He was the inventor of number of patents and published 20 papers in high impact journals.
Abstract:
WD40 repeat (WDR) domain is one of the largest protein families from yeast to human, consisting about 1% total cell protein. WDR proteins generally function as platform of protein-protein interactions and are involved in a wide range of cellular processes. Embryonic Ectoderm Development (EED), a subunit of PRC2 complex, is an important member of WDR family and plays critical role of methylating H3K27. Herein, a novel class of EED inhibitors, represented by BR554, with great drug-like properties, in vivo efficacy and favorable toxicology profile.
Break: Lunch Break: 13:00-14:00 @Public Restaurant
Trienty B G Purba
University of Indonesia, Indonesia
Title: Intra-gastric administration of mangostin microparticles encapsulated by chitosan-alginate: Acute toxicity and organs histopathological changes
Time : 14:00-14:30
Biography:
Trienty B G Purba is pursuing her undergraduation in Faculty of Medicine, University of Indonesia. She has extended her valuable service towards the scientific community with her extensive research work.
Abstract:
Statement of the Problem: Colorectal cancer is one of cancers with high incidence and its available treatments have many side effects. Therefore, it is necessary to discover a new suitable treatment with minimal systemic side effects. In recent studies, mangostin, contained in Garcinia mangostana L, has been found as a potential anticancer agent for several cancer cells. Using chitosan-alginate to encapsulate mangostin aims to achieve a good colon-targeting delivery system. This formulation is predicted as a new form of colorectal cancer targeted treatment and needs to be evaluated for its acute toxicity and effects on organs involved in digestion and excretion. Methodology & Theoretical Orientation: Six to eight weeks old BALB/c white mice were divided into 3 groups: Normal, doses of 2 and 5 g/kg body weight. The intra-gastric dose administration was given once for acute toxicity study where the mice were observed for 14 days. At last, the histopathological changes of the organs (liver, kidney, stomach and small intestine) of the sacrificed mice were also examined.
Findings: All mice were survived and no acute toxicity signs were found. Significant difference on the histopathological changes was found only in the small intestine (p=0.004). Based on that, the significant difference was found between normal and dose of 2 g/kg body weight (p=0.011) and normal and dose of 5 g/kg body weight (p=0.005). Nevertheless, there is no significant difference between dose of 2 and 5 g/kg body weight (p=0.371).
Conclusion & Significance: This study shows that doses of 2 and 5 g/kg bodyweight mangostin microparticles encapsulated by chitosan-alginate intra-gastric administration do not produce acute toxicity signs. Furthermore, the histopathological changes were found only in the small intestine.
Kenneth Thean
Ensoul Medical Clinic, Singapore
Title: Today’s advanced medical aesthetic treatments: A shift from invasive to non-invasive procedures
Time : 14:30-15:00
Biography:
Kenneth Thean has over 37 years’ experience in healthcare. His passion and academic interests lie in using medical lasers and aesthetic energy based devices. His expertise is on using customized combinations of multiple energy devices to provide anti-aging skin rejuvenation treatments. He is a Fellow of the Royal College of Surgeons of Edinburgh and the Royal College of Physicians and Surgeons of Glasgow. He is the Medical Director of Ensoul Medical Clinic in Singapore and the Medical Advisor for the Pure Laser Clinic Group and the Puro Laser Clinics in Indonesia. He was the Founder Administrator and helped establish Singapore’s National Skin Centre in 1988.
Abstract:
Medical aesthetic procedures are a growing trend in developed countries, especially among baby boomers. Better drugs and disease management has greatly prolonged our lifespan. Therefore, age management with aesthetic treatments has become a part of the regular health treatments among many individuals who want to maintain their youthful and healthy appearance. This gives greater confidence and happiness. In addition, unsightly pigmentation, scars, wrinkles and old sagging skin can now be easily and safely be treated by applying these advanced energy devices. Healthy, strong, rejuvenated skin is the desired therapeutic goal. Patients that have been psychologically affected by their appearance will parallelly be treated. Hence, a positive and healthy mental state is an outcome during these treatment processes. With today’s advances in technology, non-surgical cosmetic procedures have increased exponentially. There are now much energy based aesthetic technologies that deliver non-invasive treatments, giving rapid and efficient results with minimal complications. Treatments that are painless with no need for surgery, needles and no downtime have led to a surging of their popularity to anti-age one’s appearance. Some of these modern aesthetic instruments include medical lasers, high intensity focused ultrasound, radio frequency, microwave, light based and pneumatic devices. Scientific high-tech equipment combined with the physician’s holistic approach towards prevention and anti-aging treatments is essential. This presentation gives an overview of the current aesthetic trends and concepts, the range of treatment options, results and innovative developments of some of the prevalent non-invasive medical aesthetic treatments available.
Naeem Mubarak
International Islamic University, Malaysia
Title: Level of agreement among various health care stakeholders on collaboration between Community Pharmacist (CP) and General Practitioner (GP) for a Collaborative Medication Therapy Management (CMTM) model for Chronic Diseases (CDs) in Malaysia: A Delphi study
Time : 15:00-15:30
Biography:
Naeem Mubarak is currently pursuing PhD and his research areas include qualitative research, systematic reviews, evidence-based research, pharmacoeconomics and clinical trials.
Abstract:
Objective: Current study is the first attempt to build consensus and appraise the level of agreement (or disagreement) among various health care stakeholders on the possibilities of a CMTM model for CDs in Malaysia through Delphi technique.
Method: This Delphi study was conducted as per the COSRT guidelines. Based on a systematic literature search, an online survey was designed on QuestionPro (an online survey tool). After face and content validity of the survey, an expert panel was constructed by inviting various health care stakeholders in different organizations and professional bodies which represent GPs, CPs and Nurses, across Malaysia. Survey had 96 statements to rate using 5-point Likert scale (strongly agree to strongly disagree) and 36 ranking statements where experts were asked to rank in terms of feasibility of various aspects of the CMTM model. Consensus was pre-defined to be the point where >85% of the respondents falls in either agree or disagree category for each statement. Delphi operates in a reiterative fashion in rounds, where at the end of each round aggregate response (pooled opinion in the form of percent agreement among panel members) is presented to all experts and asked to reconsider their response in the light of the reasoning of other experts and aggregate response, if it appeals to them. This reiteration continues till there is stability (no change) in the response of experts in two consecutive rounds. Response rate was 70.73% and 100% for 1st and 2nd round respectively. Results: The percentages, Median and Interquartile Range (IQR) were calculated on the responses of experts at the end of the first round and it revealed that consensus was achieved on 105 statements and there was conflict over 27 statements. In round-2, 14 statements out of 27 conflicted statements reached the consensus after due considerations of the experts, while, 13 statements failed to stretch up to consensus. No further round was executed, as after round-2 stability in response of experts reached to 100% (Wilcoxon Signed Rank test). The inter-rater agreement was computed in both rounds using Intra-class Correlation Coefficient (ICC) (Two-way mixed model-absolute agreement, p<0.001) that is interpreted to be in between good to excellent level of agreement. Further subgroup analysis based on profession (GP, CP, Nurses) was carried out using Kruskal Wallis H-test (p<0.01), while differences in response based on experience and education were analyzed using Mann-Whitney U-test (p<0.017).
Conclusion: This study demonstrates a significant level of agreement among different health care professionals for a future role of CPs in CMTM model of CDs. Generally, there is a consensus to at least run a pilot trial of this CMTM model in major cities of Malaysia. It also highlights certain flash points where there were differences. However, study holds importance for policy makers, as the agreements or disagreements expressed in the survey may be utilized to foresee and generate guidelines and strategies to lay the foundation of a CMTM model for CDs in Malaysia.
Break: Networking & Refreshments Break: 15:30-16:00 @ Foyer
Amirah Deandra Diba
University of Indonesia, Indonesia
Title: Antioxidant properties of mangosteen pericarp extract
Time : 16:00-16:30
Biography:
Amirah Deandra Diba is a currently a fourth-year student at Faculty of Medicine, Universitas Indonesia. She is interested and open to more experiences in research, evaluation and literature studies.
Abstract:
Garcinia mangostana Linn. (GML), also known as mangosteen, is a tropical plant, most-known for its fruits, especially in Indonesia, Thailand, Sri Lanka, Malaysia, and other Southeast Asian countries. These countries have used mangosteen fruit rind (pericarp) as traditional treatments for diarrhea, dysentery, skin infections, wounds and other illnesses. GML has a great biological versatility as an interesting source of bioactive substances. These days, attention of research is focused on residual sources which are usually the waste parts of the fruit, such as the pericarp. Numerous studies have been conducted to examine and verify the medicinal properties of mangosteen pericarp. The medicinal properties verified so far are anti-inflammatory, anti-tumoral, antibacterial, antiviral, antifungal, anti-allergic and its antioxidant abilities. Many studies have examined the comparison of antioxidant activities in each part of the fruit; pericarp, stem, fruit and leaves. In those experiments, the pericarp of mangosteen extract evidently contains the strongest antioxidant activity among other parts of the fruit. Experiments have detected scavenging activities on different extracts of GML, as each scavenging activity discovered expands our knowledge of GML’s true antioxidant potential. To accompany the continuous process of discovering GML’s true antioxidant potential, we hereby conduct this review, aimed to gather current information on antioxidant properties of GML and to summarize its potential as an antioxidant agent. In addition, the analytical techniques for determining the antioxidant activity of mangosteen pericarp extract, antioxidant activity comparison for parts of mangosteen fruit and the bioactive substances discovered affecting the antioxidant activity of mangosteen pericarp extract are also discussed in this review.
Andika Trya
University of Indonesia, Indonesia
Title: Antioxidant properties of mangosteen pericarp extract
Time : 16:00-16:30
Biography:
Andika Trya is currently an undergraduate student in the Faculty of Medicine, Universitas Indonesia. His most recent interest and research focuses on Garcinia mangostana Linn. fractions and extracts. He strives to expand his knowledge and experience in the vast clinical and biomedical field of study.
Abstract:
Garcinia mangostana Linn. (GML), also known as mangosteen, is a tropical plant, most-known for its fruits, especially in Indonesia, Thailand, Sri Lanka, Malaysia, and other Southeast Asian countries. These countries have used mangosteen fruit rind (pericarp) as traditional treatments for diarrhea, dysentery, skin infections, wounds and other illnesses. GML has a great biological versatility as an interesting source of bioactive substances. These days, attention of research is focused on residual sources which are usually the waste parts of the fruit, such as the pericarp. Numerous studies have been conducted to examine and verify the medicinal properties of mangosteen pericarp. The medicinal properties verified so far are anti-inflammatory, anti-tumoral, antibacterial, antiviral, antifungal, anti-allergic and its antioxidant abilities. Many studies have examined the comparison of antioxidant activities in each part of the fruit; pericarp, stem, fruit and leaves. In those experiments, the pericarp of mangosteen extract evidently contains the strongest antioxidant activity among other parts of the fruit. Experiments have detected scavenging activities on different extracts of GML, as each scavenging activity discovered expands our knowledge of GML’s true antioxidant potential. To accompany the continuous process of discovering GML’s true antioxidant potential, we hereby conduct this review, aimed to gather current information on antioxidant properties of GML and to summarize its potential as an antioxidant agent. In addition, the analytical techniques for determining the antioxidant activity of mangosteen pericarp extract, antioxidant activity comparison for parts of mangosteen fruit and the bioactive substances discovered affecting the antioxidant activity of mangosteen pericarp extract are also discussed in this review.
Md Hasanuzzaman Sharmin Jahan
Noakhali Science and Technology University, Bangladesh
Title: Phytochemical and pharmacological evaluation of methanolic extract of fruits of Annona muricata (Linn)
Time : 16:30-17:00
Biography:
Md Hasanuzzaman is an Associate Professor of the Department of Pharmacy at Noakhali Science and Technology University, Bangladesh. He has received his PhD degree under the mentorship of Professor Jae-Gook Shin from the Department of Pharmacology, Inje University College of Medicine, Busan, Korea. He has expertise in multidrug resistance cancer, multidrug resistance tuberculosis and drug transporter research. He is also involved in phytochemical research of different medicinal plants in Bangladesh from his academic carrier since 2010. He has strong interest in pharmacogenomics and personalized medicine research in Bangladesh.
Abstract:
The present study was aimed to evaluate the phytochemical and biological investigations of fruits of Annona muricata, a plant belonging to the family of Annonaceae. The dry fruits was crushed and made powdered by a mechanical grinder and were treated with methanol using cold extraction. The crude methanolic extracts of fruits of Annona muricata was evaluated for its possible chemical group identification, antioxidant, analgesic and neuro-pharmacological activities. Phytochemical screening revealed the presence of phytoconstituents such as alkaloids, carbohydrates, tannins, saponins, phenols, flavonoids and di-terpines in methanolic crude extracts. The total phenolic content and total flavonoid was found to be 43.6 mg/gm in Gallic Acid Equivalent (GAE) and 36.05 mg/gm in Quercetin Equivalent (QE), respectively. At the evaluation of analgesic activity, crude methanolic extract of fruits of Annona muricata showed dose dependent analgesia in Swiss albino mice model. In acetic acid induced writhing test, at a dose of 200 and 400 mg/kg body weight, the extractives showed 27.78% and 42.73% inhibition of writhing, whereas aspirin as a standard yield 66.45% inhibition of writhing. In formalin induced hind paw licking test, methanolic extract showed significant amount of percentage inhibition of licking (p<0.001) in both of early phase and late phase at a dose of 200 and 400 mg/kg body weight. The crude methanol extracts of fruits was also used to evaluate anxiolytic activities such as open field, hole cross, hole board, elevated plus maze, dark light house test, forced swimming test and tail suspension test. The result from all above experiment showed that the methanolic fruit extracts of Annona muricata possesses potential anxiolytic, sedative and antidepressant activity. Further study is warranted to elucidate the exact mechanism of these pharmacological activities and to identify the active ingredients for the drug development process.
Mohammad Idzhar Arrizal
University of Indonesia, Indonesia
Title: Acute toxicity and cytotoxicity evaluation of ethyl acetate fraction of Garcinia mangostana Linn. on mice liver, kidney and intestine histopathology as an alternative therapy for colorectal cancer
Time : 17:00-17:30
Biography:
Mohammad Idzhar Arrizal is pursuing his undergraduation in Medicine at University of Indonesia. He has extended his valuable service towards the scientific community with his extensive research work.
Abstract:
Statement of the Problem: Colorectal cancer currently ranks third on the most common cancer worldwide. As treatments available, it still have many side effects to deal with, researchers have been trying to develop a new anticancer therapy with fewer side effect. Mangosteen (Garcinia mangostana Linn.), which contains α-mangostin, is known for having anticancer activity. Ethyl acetate fraction is used to obtain the highest level of α-mangostin from mangosteen. Nevertheless, its acute toxicity and cytotoxicity on liver and kidney tissues as organs involved in drug metabolism and excretion also intestines tissues as target organ have never been evaluated. The aim of this study is to evaluate the acute toxicity of ethyl acetate fraction of mangosteen extract and its cytotoxic effect on mice liver, kidney and intestine. Methodology & Theoretical Orientation: This study used 6-to-8-week-old BALB/c mice which were distributed to five groups: Control group, solvent group receiving emulsifier agent, three treatment groups receiving the extract orally at a single dose of 2, 4 and 6 g/kg BW, consecutively, each of five per group. Mice then were observed for 14 days. Afterwards, the organs were taken and examined to see any pathological changes.
Findings: The study revealed that the administration of extract at 4 and 6 g/kg BW produced toxicity signs and acute toxicity showed an approximate LD50 value at >6 g/kg BW. Meanwhile, there were no significant differences among these groups on the organs. However, the histopathology of liver indicated that the mice treated with 6 g/kg extract had significant alteration than the other groups except the solvent group.
Conclusion & Significance: Ethyl acetate fraction of mangosteen causes acute toxicity at 4 and 6 g/kg BW and has cytotoxic effect on liver tissues at 6 g/kg BW. Further studies are needed for its future development as anti-colorectal cancer therapy.
Nesrine El-Bizri
Merck Research Laboratories, USA
Title: Enhancing drug discovery efficiency: Paradigm shifts
Time : 17:30-18:00
Biography:
Nesrine El-Bizri is an Associate Principal Scientist at Merck Research Laboratories (MRL) in South San Francisco, USA. She has more than 20 years of combined PhD, Postdoctoral and biotechnology experience in the field of cardiovascular research with core expertise in in vitro, in situ and in vivo models of disease. She has a PhD in Cell Biology from the University of Sherbrooke, Quebec, Canada and has completed a Postdoctoral Fellowship in Pulmonary Arterial Hypertension at Stanford School of Medicine. She then joined Gilead in 2007 and extensively contributed to preclinical discovery research teams with focus on target validation, lead optimization and preclinical efficacy and safety research supporting the development of a molecule into phase 2/3 clinical trials in three different indications. In 2017, she joined MRL in early discovery cardiovascular group in the Department of Cardio-Renal Metabolic & Ophthalmic Discovery Biology where she is studying heart failure.
Abstract:
Drug discovery is a risky business given the high cost, the lengthy duration and the high attrition rate facing drugs during their journey from early discovery to market. To address the alarming low efficiency of drug discovery and development multiple efforts have been made in the last decade to steer the direction towards enhanced efficiency. Innovative processes or tools have been advocated for or implemented at every stage of the drug discovery and development process shifting paradigms to enhance efficiency and boost benefit versus cost in the pharmaceutical industry. Analysis has shown that paradigm shifts in the pharmaceutical industry were able to some extent to enhance efficiency of drug discovery. These paradigm shifts include implementation of the phenotypic drug discovery as compared to the classical target/hypothesis drug discovery approach leading to enhanced approval of first in class drugs. Other paradigm shifts include the adaptation of the model-based approach with computation and data mining processes as well as the reverse translation approach benefiting multiple stages in drug discovery spanning early discovery and advanced developmental clinical stages. Precision medicine ensuring delivering the right intervention for the right patient at the right time constitutes a new paradigm shift challenging the classical modality of blockbuster drugs of one fits all modality and that potentially may lead to higher efficiency in drug discovery. Finally, improving efficiency through expedited approval processes by regulators which is currently practiced approving drugs for serious/rare diseases is another way of enhancing drug development. New processes are slowly being embraced by multiple stakeholders in the pharmaceutical industry to bring new drugs to the market efficiently; however, the need for transformational tools and processes through collaborative innovation is imperative to ensure sustainability of drug discovery in the pharmaceutical industry.
- Workshop
Location: Vivaldi (4th Floor)
Session Introduction
Gabriela Zaharia Rusu
Medical Nursing & Rehabilitation Center, Israel
Title: Cognitive behavioral therapy in an older patient with a specific phobia; dromophobia: Case report
Time : 11:20-12:10
Biography:
Gabriela Zaharia Rusu is working as Chief Nurse in the Department for Rehabilitation Center, Israel. As a Health Coach, she uses a variety of health-promoting and evidence-based strategies to achieve growth, overall health and well-being of the patients, incorporating different aspects such as nutrition, stress and time management, chronic disease management and effective coping skills with each client, as well as providing comprehensive health assessments, conducting learning-style assessments to identify the best teaching methods for enhancing client understanding and empowerment.
Abstract:
This is a case report of a clinical case in which an older patient is presented motivation to modify dysfunctional avoidance behavior in order to be able to confront her phobia to cross the street. Older adult who has experienced a road accident developed fear to cross the street and is in the greater risk for physical and mental problems. Dromophobia is the fear of crossing streets; the term originated from Greek word dromo (race course) and phobia (fear). Phobias arise from the combination of external events such as traumatic events, roads accident and internal predispositions like heredity or genetics. Many specific phobias can be traced back to a specific triggering event, usually a traumatic experience at an early age. Symptoms of dromophobia vary by person depending on their level of fear. The symptoms typically include extreme anxiety, shortness of breath, rapid breathing, irregular heartbeat, sweating, nausea, dry mouth, nausea, inability to articulate words or sentences, dry mouth and shaking, muscular stiffness, avoidance to cross the street, refusal to go outside without a trusted companion (spouse) and social isolation. Cognitive Behavioral Therapy (CBT) was used to treat the patient. CBT method in dromophobia treatment was effective providing good results, improving the patient qualities of life.
- Sessions
Location: Vivaldi (4th Floor)
Session Introduction
Sung-Chen Tung
Sung-Ful Sexual Health Center, Taiwan
Title: Treatment of genito-pelvic pain/penetration disorder: From cognitive-behavioral sex therapist view
Time : 12:10-12:40
Biography:
Sung-Chen Tung is a Cognitive-Behavioral Sex Therapist and a Writer for Intimate Relationships. As the President of Chung-Hua Sexual Health Promotion Association, she aims at promoting couple’s sexual well-being and training sex therapists. She has expertise in treatment of psychogenic sexual dysfunction by CBT approach, especially on premature ejaculation, erectile dysfunction and female dyspareunia.
Abstract:
Background & Aim: Genito-Pelvic Pain/Penetration Disorder (GPPPD) is one of the leading causes of female sexual dysfunction but not well defined or understood and affects women’s sexual health and satisfaction. The purpose of this study were described the patients’ sexual behaviors before treatment and clinical experience of help-seeking for GPPPD, and compared effectiveness of intensive and weekly Cognitive Behavioral Therapy (CBT) on GPPPD. Methodology: 27 patients meeting DSM-5 criteria for GPPPD were enrolled. 14 patients from China who undertook intensive CBT (iCBT- three 1.5 hour sessions over three days) used a comparison group and 13 patients from Taiwan who undertook weekly CBT (wCBT- four 2 hour sessions over 4 weeks). All participants responded to sex history, Female Sexual Function Index (FSFI) and Sexual Anxiety Scale (SAS) before the first session and 3-month follow-up after intervention.
Result: The subjects were 31.2 years of age on average and 4.6 years of GPPPD duration. 74.1% were severe and 96.3% were lifelong GPPPD, 60.9% had non-penetrative sex and 29.6% seek for otherwise treated before for CBT intervention. At 3 months of follow up significant improvements found in lubrication (Z=-2.314, p=0.021), sexual satisfaction (Z=-2.694, p=.007), and sexual pain (-3.606, p<0.001). 25.9% had been defined normal female sexual function (FSFI>26.55) and 92.6% had intercourse in the last 1 month. iCBT had no significant reduce in SAS (p=0.374~0.953) and wCBT (p=0.005~0.196).
Conclusion: More than half of the females with GPPPD had non-penetrative sexual behaviors. iCBT and wCBT program had signiï¬cant effectiveness on reducing sexual pain and improve sexual function in GPPPD. But iCBT cannot offer cognitive restructure enough to reduce sexual anxiety.
Naeem Mubarak
International Islamic University, Malaysia
Title: A systematic review and meta-analysis of the impact of collaborative practice between community pharmacist and general practitioner on asthma management
Time : 12:40-13:10
Biography:
Naeem Mubarak is currently pursuing PhD and his research areas include qualitative research, systematic reviews, evidence-based research, pharmacoeconomics and clinical trials.
Abstract:
Objective: To evaluate the impact of collaborative practice between Community Pharmacist (CP) and General Physician (GP) in asthma management.
Methods: An extensive search was carried out in 10 databases (PubMed, Medline/Ovid, CINAHL, Scopus, Web of Science, Cochran central register of controlled trials, PsycARTICLES®, Science Direct, Education Resource Information Centre, PROQuest) and grey literature using selected MeSH and keywords such as community pharmacist, general physician, and medicine use review. After screening, 23 studies were used for evidence synthesis. The risk of bias was assessed by Cochrane risk of bias tool (EPOC). Studies were included only if there was a definite evidence of collaborative practice between CPs and GPs in management of asthma, such as CPs conducting medications reviews or providing education and counseling. The studies need to report at least one of the outcomes which include clinical, humanistic and economical. Results: A total of 23 studies (6 RCTs, 4 C-RCT, 3 controlled trials, 3 case control and 7 pre-post) were included for metaanalysis. The collaboration between CP and GP has shown consistently improvements in medication use, inhalation techniques, diseases knowledge, control of asthma, and quality of life However, clinical finding on lungs functions was not significantly improved. The collaboration was shown to be value for money, but the economic outcomes lacked RCT s designs and thus the evidence may not be considered as strong as it was for clinical and humanistic outcomes. Conclusion: The findings from this review established strong evidence in approval of the positive impact of collaborative practice between CP and GP in the management of asthma.
Break: Lunch Break: 13:10-14:10 @ Public Restaurant
Nindya Permata Bunda Surya Utami
University of Indonesia, Indonesia
Title: Centella asiatica as a potential plaque stabilizer: Future preventive therapy for cardiovascular disease
Time : 14:10-14:40
Biography:
Nindya Permata Bunda Surya Utami is an undergraduate student of Faculty of Medicine, University of Indonesia (FMUI) who has high interest in doing research. She is dedicated toward her study and always eager to learn new things.
Abstract:
WHO states that Cardiovascular Disease (CVD) is the cause of 31% of deaths worldwide reaching 17.7 million deaths per year. Causes of CVD include smoking, unbalanced food intake, low physical activity and excessive alcohol consumption. The common pathophysiology of CVD is the formation of atherosclerotic plaques which begins with endothelial dysfunction that is closely related to Diabetes Mellitus (DM). Existing treatment focus on preventing the formation of atherosclerotic plaques by lowering blood cholesterol levels and blood viscosity thereby preventing the formation of shear strength that can damage the endothelial layer. Centella asiatica (CA) is a well-known herbs used as oxidative-stress remedy. Literature review was conducted to determine its potency in preventing CVD by searching two journal databases, PubMed and EBSCOhost. The search was carried out using Boolean Operator as follows: Cardiovascular AND therapy AND Centella asiatica. Sources are not year-limited and include animal studies, RCT reports or related reviews. Based on literature review, there are various studies linking the protective effect of CA on CVD. In vivo study conducted by Ramachandran, et al. showed that in mice with DM, lipid profiles of DM mice were given asiatic acid shifted towards normalcy which reduce the risk of atherosclerotic plaque formation. RCT studies conducted by Cesarone, et al. showed that in the group given CA therapy for 12 months, there was an increase in GSM parameters and an improvement in the texture of atherosclerotic plaques which showed the formation of stable with low risk for thrombus. RCT study conducted by Luzzi, et al. on high-oxidative stress asymptomatic patients given Pycnogenol and CA extract showed an increase in the stability of atherosclerotic plaque as indicated by an increase in plaque density, decrease in the number and size of plaques. These results indicate the potential of CA as a good preventive cardiovascular therapy.
Fahad Hussain
Noakhali Science and Technology University, Bangladesh
Title: Investigation of antioxidant potentials of Acacia nilotica, Ocimum sanctum and Alpinia nigra
Time : 14:40-15:10
Biography:
Fahad Hussain is working as an Assistant Professor at Department of Pharmacy in Noakhali Science and Technology University, Bangladesh. He is also working as the Editor of few health and pharmacy related publications.
Abstract:
Acacia nilotica, Ocimum sanctum and Alpinia nigra are used traditionally in different ailments in rural settings of Bangladesh. These medicinal plants were studied for their total phenolic and total flavonoid contents as a partial approach to rationalize the use of them. Antioxidant activity was also determined measuring ferric reducing power assay and 1, 1’-Diphenyl-1Picrylhydrazyl radical (DPPH) scavenging activity. A. nilotica showed highest total phenolic content while O. sanctum showed highest flavonoid contents among the studied three plants. Similarly, IC50 values of the extracts of A. nilotica, O. sanctum and A. nigra against DPPH were 39.62, 48.81, 70.85 µg/ml, respectively. The reducing power of the extract was found to be concentration dependent and O. sanctum showed highest reducing power followed by A. nilotica. The reducing power of these two plants was fairly close to positive control ascorbic acid. Further studies are suggested such as in vivo testing and elucidation of mechanism of action of inherited bioactive compounds to support its folkloric use in the treatment of diseases.
Aisyah Aminy Maulidina
University of Indonesia, Indonesia
Title: Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to Simvastatin
Time : 15:10-15:40
Biography:
Aisyah Aminy Maulidina is currently pursuing a General Practitioner degree in Faculty of Medicine, University of Indonesia. Her interest in research is cultivated through a research module.
Abstract:
High-fructose and cholesterol diet nowadays has increased the incidence of obesity, dyslipidemia, insulin resistance, and metabolic syndrome which are the main risk factors of Non-Fatty Pancreas Disease (NAFPD), a pancreatic disease that may lead to pancreatic cancer. The pathogenesis and treatment of NAFPD is currently not well understood yet, but studies show that NAFPD is a reversible state which can be treated by modifying its underlying risk factors. The use of simvastatin in managing pancreatic disease, although was shown to reduce cancer risk and increase survival of patients with pancreatic cancer, raises concerns as simvastatin was recently found to induce diabetes and worsen hyperglycemia and A1c levels in pre-existing diabetes. A. indica Linn. is known to have flavonoids and polyphenols which may decrease serum LDL level and increase serum HDL level. A. indica Linn may also, in contrast to simvastatin, control post-prandial hyperglycemia. A study on mice induced with high fructose and a high cholesterol diet shows that A. indica Linn., with or without combination of simvastatin, helped reverse fatty formation in the pancreas. This article reviews the potential use of Acalypha indica Linn. extract as an alternative approach to modify the risk factors underlying NAFPD.
Break: Networking and Refreshments Break: 15:40-16:00 @ Foyer